Tocopherol in tumor tissues and effects of tocopherol on the development of liver tumors.
نویسندگان
چکیده
Most of the attempts made to relate vitamin E to cancer have dealt with possible effects of the vitamin on tumor formation rather than with the metabolism of vitamin E in tumor tissue. Tocoph erol has occasionally been observed to delay the development of tumors due to hydrocarbons (3,8, 9, 34), but this effect has not been consistent (5, 16), nor does vitamin E seem to affect the growth of implanted tumors (10, 22, 43). At one time wheat germ oil was considered carcinogenic (31, 32), but attempts to repeat the original ex periments failed (4, 17, 32). Vitamin E has been shown to be important in the prevention of certain liver disorders of dietary origin (18, 33), including massive hepatic necrosis caused by feeding the azo dye, p-dimethylaminoazobenzene (DAB) (15). If these results were applicable to liver tumors due to azo dyes, one might expect vitamin E to delay the formation of this latter type of tumor. How ever, no such effect was observed when rats fed DAB also received tocopherol in the relatively moderate amounts necessary to equalize the tocopherol intake of rats fed hydrogenated coco nut oil or corn oil (23). As far as we are aware, only one study has been made of the amounts of vitamin E in tumor tissue. V. Euler and v. Euler (38) reported that the Jensen sarcoma in the rat and the Brown-Pearce sarcoma in the rabbit contained 50 jug/gm and 44 jug of tocopherol/gm, respectively. In a later report (39), these workers found only 9 /ug of tocopherol/gm of tumor, an amount considered similar to that in normal tissues rich in vitamin E. The present study involves two approaches to the problem. In the first, analyses were made of the tocopherol con-
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عنوان ژورنال:
- Cancer research
دوره 11 12 شماره
صفحات -
تاریخ انتشار 1951